List of highways numbered 375

Route 375 or Highway 375 may refer to:

Canada

• Manitoba Provincial Road 375
• New Brunswick Route 375
• Saskatchewan Highway 375

Japan

• Japan National Route 375

United States

• Interstate 375
• Arkansas Highway 375
• Florida State Road 375
• Georgia State Route 375 (former)
• Maryland Route 375 (unsigned)
• Nevada State Route 375
• New York State Route 375
• Puerto Rico Highway 375
• Texas State Highway Loop 375
• Virginia State Route 375
• Wyoming Highway 375