Pentylone

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Pentylone
Clinical data
Other namesβ-Keto-Methylbenzodioxolylpentanamine, βk-Methyl-K, βk-MBDP, methylenedioxypentedrone, 1‐(3,4‐methylenedioxyphenyl)‐2‐(methylamino)pentan‐1‐one[1]
ATC code
  • None
Legal status
Legal status
Identifiers
  • (±)-1-(1,3-benzodioxol-5-yl)-2-(methylamino)pentan-1-one
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC13H17NO3
Molar mass235.283 g·mol−1
3D model (JSmol)
  • c2cc1OCOc1cc2C(=O)C(NC)CCC
  • InChI=1S/C13H17NO3/c1-3-4-10(14-2)13(15)9-5-6-11-12(7-9)17-8-16-11/h5-7,10,14H,3-4,8H2,1-2H3 ☒N
  • Key:DFMLULIEUUXXSA-UHFFFAOYSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Pentylone, also known as β-ketoN-methyl-1,3-benzodioxolylpentanamine (bk-MBDP), is a stimulant developed in the 1960s.[3] It is a substituted cathinone that has been identified in some samples of powders sold as "NRG-1", along with varying blends of other cathinone derivatives including flephedrone, MDPBP, MDPV, and 4-MePPP. It was also found in combination with 4-MePPP being sold as "NRG-3".[1] Reports indicate side effects include paranoia, agitation, and insomnia, with effects lasting for several days at high doses.[4]

Pharmacology

Pentylone acts as a serotonin–norepinephrine–dopamine reuptake inhibitor (SNDRI) and a serotonin releasing agent.[5]

Pentylone is banned in Canada, Germany, Sweden, the United States, and the United Kingdom.[6][7]

See also

References

  1. Brandt SD, Freeman S, Sumnall HR, Measham F, Cole J (September 2011). "Analysis of NRG 'legal highs' in the UK: identification and formation of novel cathinones". Drug Testing and Analysis. 3 (9): 569–575. doi:10.1002/dta.204. PMID 21960541.
  2. Anvisa (2023-07-24). "RDC Nº 804 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 804 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-07-25). Archived from the original on 2023-08-27. Retrieved 2023-08-27.
  3. GB 1085135, "Substituted phenyl-α-amino ketones.", issued 1969 
  4. Bish J (4 August 2017). "Watch Out for Pentylone, the Horrible New MDMA Additive". Vice.
  5. Simmler LD, Rickli A, Hoener MC, Liechti ME (April 2014). "Monoamine transporter and receptor interaction profiles of a new series of designer cathinones". Neuropharmacology. 79: 152–160. doi:10.1016/j.neuropharm.2013.11.008. PMID 24275046. S2CID 25259854.
  6. "Cannabinoider föreslås bli klassade som hälsofarlig vara" [Cannabinoids are proposed to be classified as a health hazard]. Folkhalsomyndigheten [Public Health Agency of Sweden] (in Swedish). Archived from the original on 25 March 2015. Retrieved 29 June 2015.
  7. "Schedules of Controlled Substances: Temporary Placement of 10 Synthetic Cathinones Into Schedule I". Drug Enforcement Administration. U.S. Federal Register. 7 March 2014.