The enzyme 3-phytase (EC 3.1.3.8) catalyzes the reaction[1][2]
- myo-inositol hexakisphosphate + H2O = 1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate
myo-Inositol hexakisphosphate is also known as phytic acid.
These enzymes belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name myo-inositol-hexakisphosphate 3-phosphohydrolase. Other names in common use include 1-phytase, phytate 1-phosphatase, phytate 3-phosphatase, and phytate 6-phosphatase.[1]
Enzymes of this type participate in inositol phosphate metabolism.
Structural studies
As of late 2007, 12 structures have been solved for this class of enzymes, with PDB accession codes PDB: 1CVM, PDB: 1IHP, PDB: 1POO, PDB: 1QFX, PDB: 1QLG, PDB: 1QWO, PDB: 1SK8, PDB: 1SK9, PDB: 1SKA, PDB: 1SKB, PDB: 2GFI, and PDB: 2POO.
See also
- 4-phytase (6-phytase)
- 5-phytase
- Protein tyrosine phosphatase
References
- "ENZYME entry 3.1.3.8". enzyme.expasy.org. Retrieved 2018-04-09.
- Mullaney EJ, Ullah AH (December 2003). "The term phytase comprises several different classes of enzymes". Biochemical and Biophysical Research Communications. 312 (1): 179–84. Bibcode:2003BBRC..312..179M. doi:10.1016/j.bbrc.2003.09.176. PMID 14630039.