BRD9

☆ Save On Wikipedia ↗
BRD9
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesBRD9, LAVS3040, PRO9856, bromodomain containing 9
External IDsOMIM: 618465; MGI: 2145317; HomoloGene: 82462; GeneCards: BRD9; OMA:BRD9 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

65980

105246

Ensembl

ENSG00000028310

ENSMUSG00000057649

UniProt

Q9H8M2

Q3UQU0

RefSeq (mRNA)

NM_001009877
NM_023924
NM_001317951

NM_001024508
NM_001308041
NM_001378947
NM_001378948

RefSeq (protein)

NP_001019679
NP_001294970
NP_001365876
NP_001365877

Location (UCSC)Chr 5: 0.85 – 0.89 MbChr 13: 73.94 – 73.96 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Bromodomain-containing protein 9 is a protein that in humans is encoded by the BRD9 gene.[5]

Structure and interaction

BRD9 contains a bromodomain. It is closely related to BRD7. BRD9 is present in some SWI/SNF ATPase remodeling complexes.[6]

Role in cancer

The BRD9 gene is frequently present in variable copy number in lung cancer.[7]

Small molecule inhibition

Small molecules capable of binding to the bromodomain of BRD9 have been developed.[8][9][10]

See also

Bromodomain

References

  1. GRCh38: Ensembl release 89: ENSG00000028310 – Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000057649 – Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: Bromodomain containing 9".
  6. Kadoch C, Hargreaves DC, Hodges C, Elias L, Ho L, Ranish J, et al. (June 2013). "Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy". Nature Genetics. 45 (6): 592–601. doi:10.1038/ng.2628. PMC 3667980. PMID 23644491.
  7. Kang JU, Koo SH, Kwon KC, Park JW, Kim JM (April 2008). "Gain at chromosomal region 5p15.33, containing TERT, is the most frequent genetic event in early stages of non-small cell lung cancer". Cancer Genetics and Cytogenetics. 182 (1): 1–11. doi:10.1016/j.cancergencyto.2007.12.004. PMID 18328944.
  8. Fedorov O, Lingard H, Wells C, Monteiro OP, Picaud S, Keates T, et al. (January 2014). "[1,2,4]triazolo[4,3-a]phthalazines: inhibitors of diverse bromodomains". Journal of Medicinal Chemistry. 57 (2): 462–476. doi:10.1021/jm401568s. PMC 3906316. PMID 24313754.
  9. Clark PG, Vieira LC, Tallant C, Fedorov O, Singleton DC, Rogers CM, et al. (May 2015). "LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor". Angewandte Chemie. 54 (21): 6217–6221. Bibcode:2015ACIE...54.6217C. doi:10.1002/anie.201501394. PMC 4449114. PMID 25864491.
  10. Theodoulou NH, Bamborough P, Bannister AJ, Becher I, Bit RA, Che KH, et al. (February 2016). "Discovery of I-BRD9, a Selective Cell Active Chemical Probe for Bromodomain Containing Protein 9 Inhibition". Journal of Medicinal Chemistry. 59 (4): 1425–1439. doi:10.1021/acs.jmedchem.5b00256. PMC 7354103. PMID 25856009.