DDX47

DDX47
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3BER
Identifiers
Aliases	DDX47, E4-DBP, HQ0256, MSTP162, RRP3, DEAD-box helicase 47
External IDs	OMIM: 615428; MGI: 1915005; HomoloGene: 6092; GeneCards: DDX47; OMA:DDX47 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12p13.1 Start 12,813,316 bp[1] End 12,829,981 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 G1 Start 134,988,575 bp[2] End 135,000,739 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in islet of Langerhans ventricular zone smooth muscle tissue skin of abdomen body of uterus body of pancreas skin of leg left lobe of thyroid gland left ovary myometrium Top expressed in tail of embryo Paneth cell Ileal epithelium primitive streak genital tubercle blastocyst morula ventricular zone renal corpuscle medullary collecting duct More reference expression data BioGPS n/a
Gene ontology Molecular function nucleotide binding protein binding hydrolase activity ATP binding helicase activity nucleic acid binding RNA binding Cellular component nucleolus membrane nucleus nucleoplasm cytoplasm Biological process mRNA processing extrinsic apoptotic signaling pathway via death domain receptors RNA secondary structure unwinding RNA splicing apoptotic process rRNA processing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51202 67755 Ensembl ENSG00000213782 ENSMUSG00000030204 UniProt Q9H0S4 Q9CWX9 RefSeq (mRNA) NM_201224 NM_016355 NM_026360 RefSeq (protein) NP_057439 NP_957518 NP_080636 Location (UCSC) Chr 12: 12.81 – 12.83 Mb Chr 6: 134.99 – 135 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Probable ATP-dependent RNA helicase DDX47 is an enzyme that in humans is encoded by the DDX47 gene.^[5]

This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene can shuttle between the nucleus and the cytoplasm, and has an RNA-independent ATPase activity. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.^[5]

References

Further reading