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Saranya P. Wyles
Dr. Saranya P Wyles
Born
Chennai, India
EducationBarnard College, Columbia University (BA)
Mayo Clinic College of Medicine (MD, PhD)
OccupationsDermatologist, Researcher
Medical career
ProfessionPhysician
FieldDermatology, Regenerative medicine
InstitutionsMayo Clinic

Saranya P. Wyles, MD, PhD, is a dermatologist, physician-scientist, clinical researcher, and thought leader in Skinspan™, a framework focused on preserving skin function, resilience, and longevity across the lifespan. Her work focuses on regenerative dermatology, skin aging biology, and the translation of regenerative therapies for age-related skin disease. Her research investigates cellular senescence, tissue regeneration, and the molecular mechanisms that drive skin aging and impaired wound healing.[1][2]

Wyles is the Director of the Regenerative Dermatology and Skin Longevity Laboratory at the Mayo Clinic and an Associate Professor of Dermatology at the Mayo Clinic College of Medicine and Science. She serves as the Medical Director for the Mayo Clinic Center for Aesthetic Medicine and Surgery. Her laboratory studies the role of senescent cells—often referred to as "zombie cells"—in aging skin and chronic wounds, with the goal of developing regenerative and senescence-targeted therapies to restore tissue function and resilience.[3][4]

Wyles defined the concept of Skinspan™, a framework that applies longevity science to dermatology by emphasizing the preservation of skin structure, regenerative capacity, and functional health over the lifespan. The concept integrates intrinsic biological aging processes with environmental factors collectively known as the skin exposome and proposes strategies to maintain long-term skin health and resilience.[5]

Her research program also explores regenerative technologies including stem cell–based therapies, acellular biotherapies such as extracellular vesicles or exosomes, and tissue-engineered skin models, including 3D bioprinted human skin systems used to study skin aging and disease.[6][7]

Early life and education

Wyles was born in southeastern India and raised in Chennai. She later moved to the United States, where she completed her undergraduate studies in Neuroscience and Art History at Barnard College in New York City. During this time, she developed an interest in stem cell research and subsequently completed a research fellowship at the Harvard Stem Cell Institute.[8][9]

She went on to earn both her Doctor of Medicine (MD) and Doctor of Philosophy (PhD) degrees from the Mayo Clinic Alix School of Medicine in Rochester, Minnesota through the institution's Medical Scientist Training Program. Following medical school, Wyles completed her dermatology residency at Mayo Clinic, where she continued her training as a physician-scientist.[10]

As part of the Mayo Scholars Program, Wyles also conducted research at King's College London and the Wake Forest Claude D. Pepper Older Americans Independence Center, where she studied skin cell atlases and the biology of human aging.[11][12]

Career

Wyles is the Director of the Regenerative Dermatology and Skin Longevity Laboratory and an Associate Professor in the Department of Dermatology at Mayo Clinic. Her clinical practice focuses on cosmetic and procedural dermatology. Wyles pioneers longevity medicine through the lens of the skin, recognizing it as a mirror of systemic health and an accessible portal for early detection, prevention, and intervention in age-related chronic and serious conditions. Her research centers on regenerative medicine, skin aging biology, and the development of biologic and regenerative therapies designed to improve skin health, extend skin and hair healthspan, and advance longevity-focused care.[13][14][15]

Her research investigates the role of cellular senescence, extracellular vesicles or exosomes, and tissue regeneration in skin aging and wound healing. Wyles has served as principal investigator on multiple clinical studies evaluating emerging regenerative approaches in dermatology and is involved in translational research aimed at bringing laboratory discoveries into clinically safe, evidence-based therapies that improve skin health, extend skin and hair healthspan, and advance longevity-focused care. Her work is grounded in the concept that skin both reflects and influences systemic aging, positioning the skin as a visible and accessible portal for understanding, monitoring, and optimizing health across the lifespan.[16][17]

Skinspan

Wyles introduced the concept of Skinspan™, a framework that applies principles of longevity science to dermatology by emphasizing the preservation of skin structure, resilience, and functional health over time rather than focusing solely on visible signs of aging. She later co-authored the publication Skinspan™: A Healthy Longevity Framework for Skin Aging (Wyles et al., 2025), which outlines a biologic model for maintaining skin health and regenerative capacity across the lifespan.[18]

In addition to her academic work, Wyles frequently lectures nationally and internationally on regenerative dermatology, longevity science, and emerging technologies in aesthetic medicine. Her work and expertise have been featured in media outlets including the NBC Today show, The Wall Street Journal, Women's Health, Vogue, Dermatology Times, and NewBeauty, among others.[19][20][21][22]

Her podcast, Mayo Clinic Skinspan™, launching July 2026, will spotlight skin as a powerful gateway to proactive health, prevention, and healthy longevity.[23]

Publications

Wyles has authored and co-authored peer-reviewed articles, review papers, and book chapters on topics including cosmetic dermatology, platelet-rich plasma, regenerative approaches to skin aging, and novel biologic therapies.[24] Selected publications include:

  • Wyles S, Proffer SL, Pastore L, Avram M, Mariwalla K, Bertucci V, Alam M. "Regenerative Medicine for Skin Health: From Principles to Practice (Part I)." Journal of the American Academy of Dermatology. 2026 Jan 30. PMID: 41621670.
  • Wyles SP, Proffer SL, Pastore L, Alam M, Avram M, Farah R, Sadick N, Hordinsky M. "Regenerative Medicine for Hair Health: From Principles to Practice (Part II)." Journal of the American Academy of Dermatology. 2026 Jan 30. PMID: 41621669.
  • Wyles SP, Maredia HS, Ansaf RB, Dweydari MR, Hurt RT, Bonnes SL, Khosla S, LeBrasseur NK, Draelos ZD, Davis MDP. "Skinspan™: A Healthy Longevity Framework for Skin Aging." Mayo Clinic Proceedings. 2025 Nov;100(11):1976–1991. PMID: 41032001; PMCID: PMC12702499.
  • Vyas KS, Kaufman J, Munavalli GS, Robertson K, Behfar A, Wyles SP. "Exosomes: the latest in regenerative aesthetics." Regenerative Medicine. 2023 Feb;18(2):181–194. PMID: 36597716.
  • Wyles SP, Carruthers JD, Dashti P, Yu G, Yap JQ, Gingery A, Tchkonia T, Kirkland J. "Cellular Senescence in Human Skin Aging: Leveraging Senotherapeutics." Gerontology. 2024;70(1):7–14. PMID: 37879300; PMCID: PMC10873061.
  • Gasek NS, Yan P, Zhu J, Purushothaman KR, Kim T, Wang L, Wang B, Flynn WF, Sun M, Guo C, Huggins B, Sharafieh R, Zhou Y, Parizek V, Tchkonia T, Kirkland JL, Wyles SP, Xu M. "Clearance of p21 highly expressing senescent cells accelerates cutaneous wound healing." Nature Aging. 2025 Jan;5(1):21–27. PMID: 39537987; PMCID: PMC12205026.
  • Yu GT, Ganier C, Allison DB, Tchkonia T, Khosla S, Kirkland JL, Lynch MD, Wyles SP. "Mapping epidermal and dermal cellular senescence in human skin aging." Aging Cell. 2025 Jan;24(1):e14358. PMID: 39370688; PMCID: PMC11709101.
  • Proffer SL, Paradise CR, DeGrazia E, Halaas Y, Durairaj KK, Somenek M, Sivly A, Boon AJ, Behfar A, Wyles SP. "Efficacy and Tolerability of Topical Platelet Exosomes for Skin Rejuvenation: Six-Week Results." Aesthetic Surgery Journal. 2022 Sep 14;42(10):1185–1193. PMID: 35689936.
  • Wyles SP, Yu GT, Ganier C, Tchkonia T, Lynch MD, Kuchel GA, Kirkland JL. "SenSkin™: a human skin-specific cellular senescence gene set." GeroScience. 2025 Jun;47(3):2631–2638. PMID: 39998731; PMCID: PMC12181445.
  • Ansaf RB, Ziebart R, Gudapati H, Simoes Torigoe RM, Victorelli S, Passos J, Wyles SP. "3D bioprinting—a model for skin aging." Regenerative Biomaterials. 2023 Jun 13. PMID: 37501679; PMCID: PMC10369216.

Awards, honors, and memberships

Wyles is considered a top authority on regenerative medicine and skin aging. She has served as the Mayo Clinic Rochester Commencement Speaker (2025) and is a recipient of the Robert and Arlene Kogod Center on Aging Career Development Award and Eugene M. Farber Travel Award for Young Investigators.[25][26]

Wyles served as chair for the research committee of the Association of Academic Cosmetic Dermatology (AACD), and active member of several professional organizations, including:[27]

  • American Academy of Dermatology (AAD)
  • Translational Geroscience Network
  • NIH Early Career Reviewer Program
  • American Society for Dermatologic Surgery (ASDS)
  • American Society for Laser Medicine and Surgery (ASLMS)
  • American Board of Dermatology (ABD)

She also serves on advisory boards and committees related to clinical research and innovation in dermatology and regenerative medicine. Wyles was selected as a Longevity Collective Lead for Estée Lauder, an initiative focused on advancing research and education related to skin longevity science.[28]

Personal life

Wyles resides in Minnesota with her family.[29]

  1. "Saranya P. Wyles, M.D., Ph.D." Mayo Clinic. Retrieved 24 June 2026.
  2. "Fighting Zombie Cells: Finding Her North Star Inside the Mayo Clinic Lab That's 3D Printing Skin". Post Bulletin. Retrieved 24 June 2026.
  3. "Saranya P. Wyles, M.D., Ph.D." Mayo Clinic. Retrieved 24 June 2026.
  4. "Fighting Zombie Cells: Finding Her North Star Inside the Mayo Clinic Lab That's 3D Printing Skin". Post Bulletin. Retrieved 24 June 2026.
  5. Wyles, Saranya P.; Maredia, H. S.; Ansaf, R. B.; Dweydari, M. R.; Hurt, R. T.; Bonnes, S. L.; Khosla, S.; LeBrasseur, N. K.; Draelos, Z. D.; Davis, M. D. P. (2025). "Skinspan™: A Healthy Longevity Framework for Skin Aging". Mayo Clinic Proceedings. 100 (11): 1976–1991. doi:10.1016/j.mayocp.2025.07.027. PMC 12702499. PMID 41032001.
  6. "Saranya P. Wyles, M.D., Ph.D." Mayo Clinic. Retrieved 24 June 2026.
  7. Ansaf, R. B.; Ziebart, R.; Gudapati, H.; Simoes Torigoe, R. M.; Victorelli, S.; Passos, J.; Wyles, Saranya P. (2023). "3D bioprinting—a model for skin aging". Regenerative Biomaterials. 10 rbad060. doi:10.1093/rb/rbad060. PMC 10369216. PMID 37501679.
  8. "Saranya P. Wyles, M.D., Ph.D." Mayo Clinic. Retrieved 24 June 2026.
  9. "Fighting Zombie Cells: Finding Her North Star Inside the Mayo Clinic Lab That's 3D Printing Skin". Post Bulletin. Retrieved 24 June 2026.
  10. "Saranya P. Wyles, M.D., Ph.D." Mayo Clinic. Retrieved 24 June 2026.
  11. "Saranya P. Wyles, M.D., Ph.D." Mayo Clinic. Retrieved 24 June 2026.
  12. "Fighting Zombie Cells: Finding Her North Star Inside the Mayo Clinic Lab That's 3D Printing Skin". Post Bulletin. Retrieved 24 June 2026.
  13. "Saranya P. Wyles, M.D., Ph.D." Mayo Clinic. Retrieved 24 June 2026.
  14. "Fighting Zombie Cells: Finding Her North Star Inside the Mayo Clinic Lab That's 3D Printing Skin". Post Bulletin. Retrieved 24 June 2026.
  15. "The Switch to Regenerative Medicine". Dermatology Times. Retrieved 24 June 2026.
  16. Wyles, Saranya P.; Carruthers, J. D.; Dashti, P.; Yu, G.; Yap, J. Q.; Gingery, A.; Tchkonia, T.; Kirkland, J. L. (2024). "Cellular Senescence in Human Skin Aging: Leveraging Senotherapeutics". Gerontology. 70 (1): 7–14. doi:10.1159/000534756. PMC 10873061. PMID 37879300.
  17. "Fighting Zombie Cells: Finding Her North Star Inside the Mayo Clinic Lab That's 3D Printing Skin". Post Bulletin. Retrieved 24 June 2026.
  18. Wyles, Saranya P.; Maredia, H. S.; Ansaf, R. B.; Dweydari, M. R.; Hurt, R. T.; Bonnes, S. L.; Khosla, S.; LeBrasseur, N. K.; Draelos, Z. D.; Davis, M. D. P. (2025). "Skinspan™: A Healthy Longevity Framework for Skin Aging". Mayo Clinic Proceedings. 100 (11): 1976–1991. doi:10.1016/j.mayocp.2025.07.027. PMC 12702499. PMID 41032001.
  19. "The Switch to Regenerative Medicine". Dermatology Times. Retrieved 24 June 2026.
  20. "Expert Insights Into the Evolving Landscape of Skincare". Dermatology Times. Retrieved 24 June 2026.
  21. "Exosomes in Skin Care". NewBeauty. 26 February 2025. Retrieved 24 June 2026.
  22. "Saranya Wyles, MD, PhD". MOA San Diego. Retrieved 24 June 2026.
  23. "Saranya P. Wyles Presentation". YouTube. 17 December 2025. Retrieved 24 June 2026.
  24. "Saranya Wyles – PubMed". Retrieved 24 June 2026.
  25. "Saranya P. Wyles, M.D., Ph.D." Mayo Clinic. Retrieved 24 June 2026.
  26. "Fighting Zombie Cells: Finding Her North Star Inside the Mayo Clinic Lab That's 3D Printing Skin". Post Bulletin. Retrieved 24 June 2026.
  27. "Saranya Wyles, MD, PhD". MOA San Diego. Retrieved 24 June 2026.
  28. "Saranya Wyles, MD, PhD". MOA San Diego. Retrieved 24 June 2026.
  29. "Saranya P. Wyles, M.D., Ph.D." Mayo Clinic. Retrieved 24 June 2026.