Probable G-protein coupled receptor 176 is a protein that in humans is encoded by the GPR176 gene..[5][6]
It is expressed by neurons in the suprachiasmatic nucleus, where it negatively regulates cAMP production in an apparently agonist-independent fashion. Its expression increases at night, indicating it may be involved in circadian rhythm within the brain. Rather than interacting with the canonical Gi protein, it interacts with Gz.[7][8]
References
- GRCh38: Ensembl release 89: ENSG00000166073 – Ensembl, May 2017
- GRCm38: Ensembl release 89: ENSMUSG00000040133 – Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- Hata S, Emi Y, Iyanagi T, Osumi T (April 1995). "cDNA cloning of a putative G protein-coupled receptor from brain". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1261 (1): 121–125. doi:10.1016/0167-4781(95)00002-x. PMID 7893747.
- "Entrez Gene: GPR176 G protein-coupled receptor 176".
- Doi M, Murai I, Kunisue S, Setsu G, Uchio N, Tanaka R, et al. (February 2016). "Gpr176 is a Gz-linked orphan G-protein-coupled receptor that sets the pace of circadian behaviour". Nature Communications. 7 (1) 10583. doi:10.1038/ncomms10583. PMC 4757782. PMID 26882873.
- Nakagawa S, Nguyen Pham KT, Shao X, Doi M (July 2020). "Time-Restricted G-Protein Signaling Pathways via GPR176, Gz, and RGS16 Set the Pace of the Master Circadian Clock in the Suprachiasmatic Nucleus". International Journal of Molecular Sciences. 21 (14): 5055. doi:10.3390/ijms21145055. PMC 7404074. PMID 32709014.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
