PF-04479745

PF-04479745
Clinical data

Other names	PF04479745; PF-4479745; PF4479745
Drug class	Serotonin 5-HT_2C receptor biased agonist; Serotonin 5-HT_2A receptor antagonist; Serotonin 5-HT_2B receptor antagonist
ATC code	None
Legal status
Legal status	In general: uncontrolled
Identifiers
IUPAC name (9S)-2-benzyl-N,9-dimethyl-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepin-4-amine
CAS Number	1065110-43-1^Y
PubChem CID	90644511
ChemSpider	34218743
UNII	73HBY5P486
ChEMBL	ChEMBL3286556
Chemical and physical data
Formula	C₁₇H₂₂N₄
Molar mass	282.391 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES C[C@H]1CNCCC2=C1N=C(N=C2NC)CC3=CC=CC=C3
InChI InChI=1S/C17H22N4/c1-12-11-19-9-8-14-16(12)20-15(21-17(14)18-2)10-13-6-4-3-5-7-13/h3-7,12,19H,8-11H2,1-2H3,(H,18,20,21)/t12-/m0/s1 Key:IHHALLDEDARSAL-LBPRGKRZSA-N

PF-04479745 is a research ligand developed by Pfizer.^[1] It is related to lorcaserin, and acts as a potent and selective agonist for the 5-HT_2C receptor, with lower affinity and antagonist action at the related 5-HT_2A and 5-HT_2B receptor subtypes.^[2]

References

"Delving into the Latest Updates on PF-4479745 with Synapse". Synapse. 24 January 2026. Retrieved 28 January 2026.
Storer RI, Brennan PE, Brown AD, Bungay PJ, Conlon KM, Corbett MS, et al. (June 2014). "Multiparameter optimization in CNS drug discovery: design of pyrimido[4,5-d]azepines as potent 5-hydroxytryptamine 2C (5-HT_2C) receptor agonists with exquisite functional selectivity over 5-HT_2A and 5-HT_2B receptors". Journal of Medicinal Chemistry. 57 (12): 5258–69. doi:10.1021/jm5003292. PMID 24878222.