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Phosphomevalonate kinase

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PMVK
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPMVK, HUMPMKI, PMK, PMKA, PMKASE, POROK1, phosphomevalonate kinase
External IDsOMIM: 607622; MGI: 1915853; HomoloGene: 4779; GeneCards: PMVK; OMA:PMVK - orthologs
EC number2.7.4.2
Orthologs
SpeciesHumanMouse
Entrez

10654

68603

Ensembl

ENSG00000163344

ENSMUSG00000027952

UniProt

Q15126

Q9D1G2

RefSeq (mRNA)

NM_006556
NM_001323011
NM_001323012
NM_001348696

NM_026784
NM_027348
NM_001310640

RefSeq (protein)

NP_001309940
NP_001309941
NP_006547
NP_001335625

NP_001297569
NP_081060
NP_081624

Location (UCSC)Chr 1: 154.92 – 154.94 MbChr 3: 89.36 – 89.38 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse
Phosphomevalonate kinase
Identifiers
EC no.2.7.4.2
CAS no.9026-46-4
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins
Phosphomevalonate kinase
Identifiers
SymbolPMVK
NCBI gene10654
HGNC9141
OMIM607622
RefSeqNM_006556
UniProtQ15126
Other data
EC number2.7.4.2
LocusChr. 1 p13-q23
Search for
StructuresSwiss-model
DomainsInterPro

Phosphomevalonate kinase is an enzyme (EC 2.7.4.2) in the mevalonate pathway[5][6][7] that in humans is encoded by the PMVK gene.

Mevalonate pathway

References

  1. GRCh38: Ensembl release 89: ENSG00000163344 – Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000027952 – Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Bloch K, Chaykin S, Phillips AH, De Waard A (October 1959). "Mevalonic acid pyrophosphate and isopentenylpyrophosphate". The Journal of Biological Chemistry. 234 (10): 2595–604. doi:10.1016/S0021-9258(18)69744-3. PMID 13801508.
  6. Henning U, Moslein EM, Lynen F (July 1959). "Biosynthesis of terpenes. V. Formation of 5-pyrophosphomevalonic acid by phosphomevalonic kinase". Archives of Biochemistry and Biophysics. 83 (1): 259–67. doi:10.1016/0003-9861(59)90031-1. PMID 13662013.
  7. Levy HR, Popjak G (June 1960). "Studies on the biosynthesis of cholesterol. 10. Mevalonic kinase from liver". The Biochemical Journal. 75 (3): 417–28. doi:10.1042/bj0750417. PMC 1204488. PMID 14416398.